Research Article | | Peer-Reviewed

Study on the Hemostatic Effect of Semen Vaccariae Before and After Charcoal Preparation

Received: 3 February 2024     Accepted: 26 February 2024     Published: 19 March 2024
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Abstract

Aims: This study is aimed to verify the records in ancient Chinese classics that semen vaccariae was mainly used for traumatic hemorrhage caused by metal sharp weapons but need to be burned into ash first. Methods: The bleeding time and clotting time of tail-amputated bleeding experiment and capillary coagulation experiment of mice were measured to evaluate the hemostatic effect of semen vaccariae before and after charcoal preparation. Results: While semen vaccariae was used topically to mice, the bleeding time of charcoal group was significantly shortened (P < 0.05), but there was no significant difference in raw group. While semen vaccariae was used orally to mice, the bleeding time and clotting time in the low and high dose groups of raw groups decreased significantly (P < 0.05 or 0.01). In addition, the bleeding time in the high dose of raw group also decreased significantly (P < 0.05). However, animal death and animal weight loss were found in the raw group during the experiment. The clotting time was also decreased significantly in low, middle and high dose charcoal groups (P < 0.05 or 0.01). Conclusions: Semen vaccariae used topically after charcoal preparation has hemostatic effect, while semen vaccariae used orally both before and after charcoal preparation shows hemostatic effect, but raw semen vaccariae used orally has potential risk. This study to some extent verifies the records in ancient Chinese classics.

Published in International Journal of Chinese Medicine (Volume 8, Issue 1)
DOI 10.11648/j.ijcm.20240801.11
Page(s) 1-6
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Semen Vaccariae, Hemostatic Effect, Charcoal Preparation, Tail-Amputated Bleeding Experiment

References
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[4] Zhang He, Xu Yuanyan, Wang Minghui et al. Modern research progress of the theory of "carbonic herbs for hemostasis " in Chinese materia medica [J]. World Science and Technology - Modernization of Traditional Chinese Medicine, 2023, 25(04): 1502-1510.
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  • APA Style

    Zhang, Y., Liu, Z., Liu, J., Zhou, G. (2024). Study on the Hemostatic Effect of Semen Vaccariae Before and After Charcoal Preparation. International Journal of Chinese Medicine, 8(1), 1-6. https://doi.org/10.11648/j.ijcm.20240801.11

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    ACS Style

    Zhang, Y.; Liu, Z.; Liu, J.; Zhou, G. Study on the Hemostatic Effect of Semen Vaccariae Before and After Charcoal Preparation. Int. J. Chin. Med. 2024, 8(1), 1-6. doi: 10.11648/j.ijcm.20240801.11

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    AMA Style

    Zhang Y, Liu Z, Liu J, Zhou G. Study on the Hemostatic Effect of Semen Vaccariae Before and After Charcoal Preparation. Int J Chin Med. 2024;8(1):1-6. doi: 10.11648/j.ijcm.20240801.11

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  • @article{10.11648/j.ijcm.20240801.11,
      author = {Yaosheng Zhang and Zeqiang Liu and Jia Liu and Guohong Zhou},
      title = {Study on the Hemostatic Effect of Semen Vaccariae Before and After Charcoal Preparation},
      journal = {International Journal of Chinese Medicine},
      volume = {8},
      number = {1},
      pages = {1-6},
      doi = {10.11648/j.ijcm.20240801.11},
      url = {https://doi.org/10.11648/j.ijcm.20240801.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20240801.11},
      abstract = {Aims: This study is aimed to verify the records in ancient Chinese classics that semen vaccariae was mainly used for traumatic hemorrhage caused by metal sharp weapons but need to be burned into ash first. Methods: The bleeding time and clotting time of tail-amputated bleeding experiment and capillary coagulation experiment of mice were measured to evaluate the hemostatic effect of semen vaccariae before and after charcoal preparation. Results: While semen vaccariae was used topically to mice, the bleeding time of charcoal group was significantly shortened (P Conclusions: Semen vaccariae used topically after charcoal preparation has hemostatic effect, while semen vaccariae used orally both before and after charcoal preparation shows hemostatic effect, but raw semen vaccariae used orally has potential risk. This study to some extent verifies the records in ancient Chinese classics.
    },
     year = {2024}
    }
    

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    T1  - Study on the Hemostatic Effect of Semen Vaccariae Before and After Charcoal Preparation
    AU  - Yaosheng Zhang
    AU  - Zeqiang Liu
    AU  - Jia Liu
    AU  - Guohong Zhou
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    DO  - 10.11648/j.ijcm.20240801.11
    T2  - International Journal of Chinese Medicine
    JF  - International Journal of Chinese Medicine
    JO  - International Journal of Chinese Medicine
    SP  - 1
    EP  - 6
    PB  - Science Publishing Group
    SN  - 2578-9473
    UR  - https://doi.org/10.11648/j.ijcm.20240801.11
    AB  - Aims: This study is aimed to verify the records in ancient Chinese classics that semen vaccariae was mainly used for traumatic hemorrhage caused by metal sharp weapons but need to be burned into ash first. Methods: The bleeding time and clotting time of tail-amputated bleeding experiment and capillary coagulation experiment of mice were measured to evaluate the hemostatic effect of semen vaccariae before and after charcoal preparation. Results: While semen vaccariae was used topically to mice, the bleeding time of charcoal group was significantly shortened (P Conclusions: Semen vaccariae used topically after charcoal preparation has hemostatic effect, while semen vaccariae used orally both before and after charcoal preparation shows hemostatic effect, but raw semen vaccariae used orally has potential risk. This study to some extent verifies the records in ancient Chinese classics.
    
    VL  - 8
    IS  - 1
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Author Information
  • School of Traditional Chinese Medicine and Health, Guangzhou Nanfang College, Guangzhou, China; College of Pharmacy, Guangdong Medical University, Guangzhou, China

  • College of Pharmacy, Guangdong Medical University, Guangzhou, China

  • School of Traditional Chinese Medicine, Guangdong Food and Drug Vocational College, Guangzhou, China

  • School of Traditional Chinese Medicine and Health, Guangzhou Nanfang College, Guangzhou, China

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